CURRICULUM of the ANKARA UNIVERSITY of FACULTY of PHARMACY

T: Theoretical, P: Practical

1st Year

Fall Semester

Code

Course

T/P

hr/week

Total

ECTS Credit

Teo

Pra

ATA101

Principles of Ataturk and History of the Turkish Republic I

T

2

-

2

1

YDI101

Foreign Language (English) I

T

4

-

4

1

TDI101

Turkish Language I

T

2

-

2

1

FIZ131

Physics

T

2

-

2

4

MAT123

Mathematics

T

2

-

2

5

ECZ155

Plant Biology

T

2

-

2

5

ECZ157

General Chemistry I

T

3

-

3

6

ECZ159

Pharmacy Orientation

T

2

-

2

6

ENF101

Fundamentals of Computer Science

T

2

-

2

1

Total

21

 

21

30

 

Spring Semester

Code

Course

T/P

hr/week

Total

ECTS Credit

Teo

Pra

ATA102

Principles of Ataturk and History of the Turkish Republic II

T

2

-

2

1

YDI102

Foreign Language (English) II

T

4

-

4

1

TDI102

Turkish Language II

T

2

-

2

1

ECZ150

Medical Biology

T

2

-

2

4

ECZ152

Pharmaceutical Botany

T

3

-

3

4

ECZ154

Pharmaceutical Botany

P

-

4

4

4

ECZ156

General Chemistry II

T

2

-

2

4

ECZ158

Biostatistics

T

2

-

2

3

ECZ160

Human Anatomy

T

2

 

2

4

ECZ162

Public Health

T

1

-

1

2

*BED102 Physical Education

*MUZ102 Music

*GUS104 Fine Art

P

 

2

2

2

Total

20

6

26

30

* * A total of 2 ECTS credits are required from this group.

 

 

 

 

 

2nd Year

Fall Semester

Code

Course

T/P

hr/week

Total

ECTS Credit

Teo

Pra

YDI201

Foreign Language

(English) III

T

4

-

4

1

ECZ281

Analytical Chemistry I

T

3

-

3

4

ECZ283

Analytical Chemistry I (Pra)

P

-

4

4

5

ECZ285

Organic Chemistry I

T

2

-

2

4

ECZ287

Pharmaceutical

Microbiology and

Immunology

T

3

-

3

4

ECZ289

Biochemistry I

T

2

-

2

3

ECZ291

Human Physiology

T

3

-

3

5

ECZ295

History of Pharmacy

and Deontology

T

1

-

1

2

ECZ601-606

*Ist Group Elective

Courses

T

2

-

2

2

Total

20

4

24

30

* A total of 2 ECTS credits are required from this group.

 

Spring Semester

Code

Course

T/P

hr/week

Total

ECTS Credit

Teo

Pra

YDI202

Foreign Language

(English) IV

T

4

-

4

1

ECZ280

Analytical Chemistry II

T

3

-

3

4

ECZ282

Analytical Chemistry II

P

-

4

4

4

ECZ284

Organic Chemistry II

T

3

-

3

4

ECZ286

Pharmaceutical

Microbiology

T

2

-

2

3

ECZ288

Pharmaceutical

Microbiology

P

-

4

4

4

ECZ290

Biochemistry II

T

3

-

3

4

ECZ292

Biochemistry (Pra)

P

-

4

4

4

ECZ601-606

* Ist Group Elective

Courses

T

2

-

2

2

Total

17

12

29

30

* A total of 2 ECTS credits are required from this group.

 

 

 

 

 

3rd Year

Fall Semester

Code

Course

T/P

hr/week

Total

ECTS Credit

Teo

Pra

ECZ381

Pharmacognosy I

T

2

-

2

3

ECZ383

Pharmacognosy I Pra.

P

-

4

4

2

ECZ385

Pharmaceutical

Chemistry I

T

4

-

4

5

ECZ387

Pharmaceutical

Chemistry I Pra.

P

-

4

4

2

ECZ389

Pharmaceutical

Technology I

T

3

-

3

4

ECZ391

Pharmaceutical

Technology I Pra.

P

-

4

4

3

ECZ393

Pharmacology I

T

4

-

4

5

ECZ395

Clinical Biochemistry

T

1

-

1

2

ECZ701-733

**IInd Group Elective

Courses

T

2

-

2

4

Total

16

12

28

30

** A total of 4 ECTS credits are required from this group.

 

Spring Semester

Code

Course

T/P

hr/week

Total

ECTS Credit

Teo

Pra

ECZ382

Pharmacognosy II

T

2

-

2

2

ECZ384

Pharmacognosy II Pra

P

-

4

4

4

ECZ386

Pharmaceutical

Chemistry II

T

3

-

3

4

ECZ388

Pharmaceutical

Chemistry II Pra

P

-

4

4

4

ECZ390

Pharmaceutical

Technology II

T

3

-

3

4

ECZ392

Pharmaceutical

Technology II Pra

P

-

4

4

3

ECZ394

Pharmacology II

T

3

-

3

3

ECZ396

Physiopathology

T

2

 

2

2

ECZ701-733

* *IInd Group Elective

Courses

T

2

-

2

4

Total

15

12

27

30

** A total of 4 ECTS credits are required from this group.

 

 

 

 

 

4th Year

Fall Semester

Code

Course

T/P

hr/week

Total

ECTS Credit

Teo

Pra

ECZ481

Pharmacognosy III

T

2

-

2

3

ECZ483

Pharmacognosy III Pra

P

-

4

4

3

ECZ485

Pharmaceutical

Chemistry III

T

2

-

2

2

ECZ487

Pharmaceutical

Chemistry III Pra

P

-

4

4

3

ECZ489

Pharmaceutical

Technology III

T

3

-

3

3

ECZ491

Pharmaceutical

Technology III Pra

P

-

4

4

2

ECZ493

Pharmaceutical Toxicology I

T

2

-

2

3

ECZ495

Pharmaceutical Toxicology I Pra

P

-

2

2

1

ECZ497

Pharmaceutical Legislation

and Management

T

2

-

2

3

ECZ499

Pharmacology III

T

2

-

2

3

ECZ701-733

**IInd Group Elective

Courses

T

2

-

2

4

Total

15

14

29

30

** A total of 4 ECTS credits are required from this group.

 

Spring Semester

Code

Course

T/P

hr/week

Total

ECTS Credit

Teo

Pra

ECZ482

Pharmaceutical

Chemistry IV

T

2

-

2

3

ECZ484

Pharmaceutical

Chemistry IV

P

-

4

4

2

ECZ486

Pharmaceutical

Technology IV

T

4

-

4

4

ECZ488

Pharmaceutical

Technology IV

P

-

4

4

4

ECZ490

Pharmaceutical Toxicology II

T

2

-

2

3

ECZ492

Pharmaceutical Toxicology II

P

-

4

4

2

ECZ494

Pharmacotherapy

T

2

-

2

3

ECZ496

Pharmaceutical Care

T

2

-

2

3

ECZ498

Family Planning

T

1

-

1

1

ECZ500

Medical First Aid

T

1

-

1

1

ECZ701-733

**IInd Group Elective

Courses

T

2

-

2

4

Total

16

12

28

30

** A total of 4 ECTS credits are required from this group.

 

 

5th Year

Fall Semester

Code

Course

T/P

hr/week

Total

ECTS Credit

Teo

Pra

ECZ506-551

***IIInd Group Elective

Courses (In the fields of

Industry/Hospital/Community

Pharmacy)

P

10

-

10

10

ECZ501

Graduation Project Course

T

3

-

3

8

ECZ503

Graduation Project Application  Course

P

-

12

12

12

Total

15

12

25

30

*** A total of 10 ECTS credits are required from this group.

 

Spring Semester

Code

Course

T/P

hr/week

Total

ECTS Credit

Teo

Pra

ECZ502

Graduation Project Course

T

3

-

3

5

ECZ502

Graduation Project

P

-

12

12

10

ECZ504

Training

P

1

14

15

15

Total

4

26

30

30

 

 

 

 

 

 

 Total ECTS credits: 300

 

Course Description of the Obligatory Courses

(FIZ131) PHYSICS (T) 

HOUR/WEEK : 2, ECTS: 4

Measurement in Physics (Physical magnitude, standards, unit systems),vectors(addition and multiplication), Motion along a line(Velocity, acceleration, freely falling), dynamic of particle I,II,(Newton’s Law, frictionless and frictional motion),Work and Energy (Work- Energy Theorem, Power), The Energy Conservation Law (Potential Energy, Kinetic Energy, Conservation of total Energy), dynamic of particle systems (Mass center, linear momentum and it is conservation)  and collision, Charge and matter (Coulemb’s Law, Electrical Charge Conservation), Electric Field (E) (Calculation of Electric Field, Point Charge in a Electric Field), Electric Potential (Potential and Potential Energy realizing to groups of point charge), Capacitors and Dielectrics(Calculation of capacitance, capacitance in the dielectric Media), Electric Circuits(Current and Potential Calculations in a single and Multiloop circuit), Magnetic Field (Bdefined, Magnetic Force on a current-carrying conductor) subjects are involved.

(MAT123) MATHEMATICS (T)

HOUR/WEEK : 2, ECTS : 5

Sets, Real numbers, Inequalities, Graphs of equations, Functions, Graph of a function, Types of Functions, Limits of functions, Right and left hand limits, Continuity, Theorems of continuity, Derivatives, Derivatives of functions, Rules for derivatives. Applications of derivatives. Differentials. Indefinite Integrals. Rules for Integrals. Definite integrals. Applications of integrals. Vector algebra. Matrices. Determinants.

(ECZ155) PLANT BIOLOGY (T)

HOUR/WEEK : 2, ECTS: 5

What is Biology?, Branches of Biology, Beginning of Modern Biology, Species, The Concept of Evolutionary Alteration, Principles of Evolution, Chemical Basis of Life on Earth, Inorganic Compounds (elements, water, carbon dioxide, oxygen), Organic Compounds (carbohydrate, lipids, proteins, enzymes, nucleic acids), Cell, Cell Research Methods, General Characteristics, Microscopically Structure of Cell, Cell Membrane, Cell Wall, Protoplasm, Cytosol, Organelles, Endoplasmic Reticulum, Ribosomes, Golgi Apparatus, Peroxisome, Mitochondria, Plastids, Vacuoles, Nucleus, Chromosomes, Plant Development, Plant Tissues, Meristemmatic Tissues, Permanent Tissues, Fundamental Tissues, Protective Tissues, Conductive Tissues, Supporting Tissues, Secretion Tissues, Plant Organs, Root, Stem, Leaf, Photosynthesis, Photorespiration, Flower, Fruit, Seed.

(ECZ157) GENERAL CHEMISTRY I (T)

HOUR /WEEK : 3, ECTS: 6

Structure of atom, its theories (discovery of electrons and nucleus), properties of atoms; Periodic system (general properties): energy level of electrons, wave characteristics of electrons, spin of electrons, quantum number, atomic radius, ionization potential (ionization energies), electron affinity, Chemical bonding: electronegativity, molecular geometry, hybridization, molecular orbitals (theory and their shapes), Stoichiometry: atom-gr, mole and equivalent gram concepts, calculation of empirical formulae, calculation of molecular formulae, chemical reactions oxidation number; Redox: balancing the chemical equations, chemical equations and related calculations, Gases: gas laws (Boyle’s law, Charles’s law, Dalton’s law, Avagadro principle, Graham’s law, equations of state), the kinetic theory of gases, real gases, the ideal gases, liquification of gases, dissolution of gases in liquids, Henry’s law, related problems, liquids: general properties, equilibrium vapor pressure, boiling point, heating and cooling curves; phase diagrams, related problems, Solutions: concentration units, vapor pressure (Raoult’s law), boiling point, freezing point; electrolytes, percent resolution, interionic forces of attraction, solubility, related problems, Solids: general properties, geometry of solid, related problems

(ECZ156) GENERAL CHEMISTRY II (T)     

HOUR /WEEK : 2, ECTS:4

Chemical kinetics: reaction rates, concentration which is effective on rate, rate equations, other factors which are effective on rate (temperature, catalyzer, activation energy), order of reactions and determination methods, collision theory, absolute reaction rate theory and calculations, Chemical equilibrium: equilibrium state, mass action, equilibrium constants, Le Chatelier’s principle, factors which are effective on the equilibrium, heterogeneous equilibrium and related calculations; Electrochemistry: electrical conductivity, electrolyses and law’s, galvanic cell, Nernst equation and related problems; Nuclear chemistry: structure of nucleus, radioactivity, nuclear energy ,nuclear reactions and examples, radiochemistry, nuclear fission and fusion and problems; Thermodynamic: systems and functions, laws of thermodynamic, the first law of thermodynamic, energy, enthalpy, the second law of thermodynamic, entropy, chemical activity, the Gibbs free energy and chemical equilibrium, related problems.

(ECZ159) GUIDANCE TO PHARMACY (T)

HOUR / WEEK : 2, ECTS:4

Introduction, constitutional provisions about universities, fundamental conceptions in higher education law, university, faculty, college, section, department, discipline concepts, introduction of University of Ankara, introduction of Pharmacy Faculty of University of Ankara, introduction of their academically and administrative structure, sections, departments, and disciplines, administrative units, education regulations, training course instructions, student discipline regulation, graduate and postgraduate education in pharmacy, conceptions of pharmacy and pharmacist, duties, responsibilities, international associations establishments about pharmacy, Ministry of Health, Ministry of Labor and Social Security, Turkish Pharmacists Association, regional pharmacist chambers, World Health Organization, International Pharmaceutical Federation, several foreign pharmacy associations, conceptions of health and illness, medicine, conceptions of active substance of medicine and excipient substance of medicine, classification of medicines, pricing of medicines, conception of pharmacy shop, conception of pharmaceutical warehouse, introduction of pharmaceutical industry, duties and responsibilities of a pharmacist in health protection and therapy, pharmacist-patient relationships, conception of prescription, conceptions of deontology and ethics, conception of research and publication in pharmacy, introduction of important pharmaceutical journals.

ENF101 Fundamentals of Computer Science (T)

HOUR/WEEK :2, ECTS:1

A brief information on history of computer, a brief information on the hardware (Main board, Memory, Central Processing Unit (CPU) etc.), Input devices, Output devices, Input/Output devices; Disc operating systems, WINDOWS operating system, general properties of WINDOWS; Word processors, Microsoft Word 2000, loading Microsoft Word 2000, Menus; File, Edit, View, Insert, Format, Tools; Microsoft Excel 2000, loading Microsoft Excel, calculation chart and formulas, order of arithmetic, graphs; Microsoft PowerPoint 2000, loading PowerPoint, creating new slide, editing slide; Data transfer between Microsoft office programs, object linking, object embedding, copy-paste.

(ECZ150) MEDICAL BIOLOGY (T)

HOUR/WEEK :2, ECTS:4

Description of Medical Biology, Comparison of Plant and Animal Cells, Cell Division, Amitosis, Mitosis, Cytokinesis, Meiosis, Comparison of Mitosis and Meiosis, Cytological and Genetic Importance of Cell Division, Cell Metabolism, Nutrition, Cellular Respiration and Energy, Comparison of Respiration and Photosynthesis, Genetic Material, DNA, RNA, Gene, Replication of DNA, Repair of DNA, Transcription, Translation, Genetic Code, Decoding, Synthesis of A Protein Molecule,  Roles and Effects of Proteins in Cell Cycle,  Gene Transfer, Cellular Aging, Cellular Death, Reproduction of Organisms, Asexual Reproduction, Sexual Reproduction, Reproduction of Animals, Sperm Structure, Ovule Structure, Gametogenesis, Fertilization, Animal Tissues, Epithelium, Connective Tissue, Blood, Muscle, Nerve, Genetics,  History of Genetics, Mendel Genetics, Monohybrid Crossing, Punnett Squares, Dihybrid Crossing, Phenotype and Genotype, Chromosome Mutations, Ethics of Genetically Technology, Human Genome Project and Expectations.

ECZ158  BIOSTATISTICS (T)     

HOUR/WEEK :2, ECTS:3

The basic concepts of statistics; Descriptive statistics, Measures of central tendency; Measures of dispersion; Statistical distributions; Binomial distribution, Poisson distribution, Normal distribution, standard normal distribution; Correlation coefficient, regression coefficients, regression equation, regression line, determination coefficient; Sampling distributions; Hypothesis testing, hypotheses, test statistics, Type I and Type II errors, one- and two tailed tests; Z-distribution and hypothesis testing; t-distribution and hypothesis testing; Confidence intervals; Chi-square distribution, test of homogeneity, tests of goodness-of-fit, test of independence, F-distribution, analysis of variance technique, multiple comparison tests (least significant difference, Tukey (a) method).

(ECZ152) PHARMACEUTICAL BOTANY (T)    

HOUR /WEEK  :3, ECTS:4

Distribution of medicinal plants according to the phylogenetics system, their general features, usages, drugs obtained from them, major active substances and their effects are examined. In addition,  Flora of Turkey is also introduced. Poisonous plants, economical plants and the ones used in traditional medicine are also within the scope of the lecture. Under this scope, the main titles are: Nomenclature of Plants and Drugs, Classification of Plants, Bacteriophyta, Phycophyta, Mycophyta, Pteridophyta, Spermatophyta, Gymnospermae, Angiospermae, Monocotyledonae, Dicotyledonae, Apetalae, Dialypetalae, Sympetalae.

(ECZ154) PHARMACEUTICAL BOTANY (P)     

HOUR /WEEK :4, ECTS:4

Leaves and other organs of plants that are used in the treatment; and also specimens belonging to lichens, mushrooms (fungi), pteridophytes and conifers are examined. The morphological and anatomical structures of the organs like leaf, cortex, radix, fruit and flower of the plants used in the treatment are examined. The examination of the characteristic elements of herbal teas and powdered drugs by means of microscope are within the scope of this lecture. Under this scope the main titles are; Leaf morphology, Microscopically Analysis of Starches, Lichens, Pteridophyta, Cross-Section and Powdered Drug Analysis of Leaf, Cross-Section and Powdered Drug Analysis of Underground Parts, Cross-Section and Powdered Drug Analysis of Cortex, Flower Morphology, Microscopically Analysis of Herbal Teas, Microscopically Analysis of Narcotic Herbs.

(ECZ160) ANATOMY (R)      

HOUR / WEEK :2, ECTS:4

The aim of Human anatomy course is to describe the relationship between form and function. The main topics are locomotor system, (knowledge of bone, joint and vurcle ), peripheral vessels, organ system, central nervous system and sense organs.

(ECZ162) PUBLIC HEALTH (T)

HOUR /WEEK  :1, ECTS:2

General introduction to health, studies in public health, health care and laws in Turkey, mortality and morbidity rates, infectious diseases, immunization and related programs, nutrition in the context of public health, environmental health, health education, hygiene

(ECZ281) ANALYTICAL CHEMISTRY I (T)   

HOUR/WEEK :3, ECTS:4

Law of mass action, solutions  and    concentration units of the solutions, neutralimetry, pH-value, pH calculations, buffer solutions, calculations in  titrimetry, indicators, neutralization titrations (acid-base titrations) and related examples, theory of redox  (concepts, calculations of potentials, redox titrations, examples), precipitation (reactions, titrations, examples and calculations) and problems about all the methods.

(ECZ280) ANALYTICAL CHEMISTRY II (T)   

HOUR /WEEK :3, ECTS : 4

Complexes (theory, classification, calculations, examples for complexometric titrations,) activity, activity  coefficient (concept and mathematical bases), Instrumental analysis; Spectrophotometric methods (concepts, classification, atomic absorption, UV-Visible and IR  spectrophotometry), their applications and calculations; Electroanalytical methods; potentiometry  (electrodes and titrations), voltammetry and polarography  and, conductometry (theory, applications and calculations), Separation techniques; chromatographic  separations (theory, types of chromatography, their applications and calculations), polarimetry and other spectroscopic methods; mass spectrometry  and NMR (theories, their applications and calculations)

(ECZ283) ANALYTICAL CHEMISTRY I PRACTICE (P)    

HOUR /WEEK :4, ECTS:5

In this laboratory, qualitative analyses of anions and cations are realized. Theoretical explanation of the analysis is given at the beginning of each laboratory study. This is followed by the qualitative experiment for the investigated ions. Unknown samples are given for each group and the experiments are realized based on the systematic analysis. Moreover, material knowledge and the principles of the systematic analysis are described.

(ECZ282) ANALYTICAL CHEMISTRY II PRACTICE (P)    

HOUR / WEEK :4, ECTS:4

The quantitative analyses are realized in this laboratory. Active compounds in drugs, as in solution and solid type, have been quantitatively determined using titrimetric analysis (based on acid-base, redox, precipitation and complexation reactions), gravimetric, spectrophotometric, electroanalytic (potentiometric and polarographic techniques) and chromatographic techniques (TLC, paper and HPLC analysis) the evaluation of the experimental results, are within the scope of this laboratory.

(ECZ285) ORGANIC CHEMISTRY I (T)

HOUR / WEEK  :2, ECTS:4

1. Introduction to organic chemistry, a. Electronic configuration of carbon and types of chemical bonding, b. Functional groups, c. Nomenclature of organic compounds, d. Isomerism, e. Charge distribution and polarization of bonds (mesomeric and inductive effects), f. Acidity and basisity of organic molecules, g. Organic reactions, 2. Organic reactions (In aliphatic compounds), a. Hydrocarbons, b. Halogenated hydrocarbons,      c. organometallic compounds.

(ECZ284) ORGANIC CHEMISTRY II (T)    

HOUR /WEEK  :3, ECTS :4

1. Chemistry of Organic compounds (Aliphatics) a. Alcohols, b. Polyols, c. Ethers, d. Thiols and other sulphur containing compounds, e. Amines and derivatives, f. Carbonyl compounds, g. Carboxylic acids and derivatives, 2. Introduction to aromatic compounds, a. Aromaticity, aromatic properties, b. Electrophilic substitution mechanism in aromatic compounds, c. Nomenclature in aromatic compounds, d. Benzene and other aromatic hydrocarbons, e. Halobenzenes , f. Phenols, f. Aromatic amines, g. Carboxylic acids and arylsulphonic acids, h. Heterocyclic compounds, nomenclature, general synthesis method of heterocyclic compounds.

(ECZ287) PHARMACEUTICAL MICROBIOLOGY AND IMMUNOLOGY (T)   

HOUR/WEEK :3, ECTS:4

History and importance of microbiology, Classification of microorganisms and classification criteria, Structures of microorganisms, Reproduction of microorganisms, Metabolisms of microorganisms and their enzymes, Genetics of bacteria, Variations on microorganisms, Transfer methods of genetic materials in bacteria, Effects of environment on microorganisms, Sterilization and Sterilization methods, Disinfection and antisepsis, Chemotherapeutic drugs and their effect mechanisms on microorganisms, Relationship between microorganisms and their environment, Parasitismus, Resistance of living-organism to microorganisms, Acquired immunity, Immune response, Antigens, Antibodies, Mechanism of immune response, Interleukins and Interferons, Apoptosis, Types of sensitivity reactions, Tumor immunology, Transplantation immunology, Vaccines and Immune serums.

(ECZ286) PHARMACEUTICAL MICROBIOLOGY (T)     

HOUR /WEEK  : 2, ECTS:3

Virology, Bacteriology, Vibrionaceae, Non-fermentative gram negative bacilli, Aerobe gram negative small bacilli, Facultative anaerobe gram negative bacilli, Curved gram negative bacilli, Gram positive cocci, Neisseriaceae, spore-forming gram positive bacilli, non-spore-forming gram positive bacilli, Actinomyces and Nocardia, Spirochaetaceae, Mycoplasmataceae, Rickettsiaceae, Chlamydiaceae.

(ECZ288) PHARMACEUTICAL MICROBIOLOGY PRACTICAL (P)      

HOUR/WEEK  :4, ECTS:4

Tools and materials that used in microbiology laboratory, Culture media,  Biochemical identification tests for bacteria, Identification methods of bacteria, Capsule and spore staining procedures, Simple and gram staining procedures, Antimicrobial susceptibility testing for bacteria, Serologic reactions, Mycobacteriaceae, Laboratory animals and inoculation methods, Microbiologic quality controls of the drugs, Tissue culture, Inoculation methods to chicken egg with embryo, Parasitic examination of blood and stool specimens,

(ECZ289) BIOCHEMISTRY I (T)    

HOUR /WEEK  :2, ECTS :3

Protein Chemistry, Enzymes, Coenzymes and Vitamins, Carbohydrate Chemistry and Metabolism

And Biological Oxidation.
(ECZ290) BIOCHEMISTRY II (T)     

HOUR/WEEK :3, ECTS:4

Chemistry and Metabolism of Lipids, Metabolism of  Proteins and Amino Acids, Chemistry  and

Metabolism of Nucleic Acids, Protein Biosynthesis and its Regulation, Hormones, Acid and Base

Equilibria, Minerals
(ECZ292) BİOCHEMİCAL PRACTİCE (P)     

HOUR / WEEK :4, ECTS :4

Qualitative and Quantitative analysis of Carbohydrates, Lipids and Proteins,  blood and urine analysis, several enzyme tests evaluation of the biochemical tests and clinical information.

(ECZ291) PHYSIOLOGY (T)     

HOUR/WEEK :3, ECTS:5

Functional organization of body and homeostasis, cellular physiology , structure of cell membrane and transport across cell membranes, intercellular communications, physiology of nerve and muscle cells, nervous system, cardiovascular system, respiratory system, gastrointestinal  system, urinary system, endocrinology and reproductive system

(ECZ295) PHARMACY HISTORY AND DEONTOLOGY (T)     

HOUR/WEEK :1, ECTS :2

Historical evolution of pharmacy is taught in history methodology; especially Turkish Pharmacy History from the Seljuk Anatolia and history of pharmaceutical industry and publications are taught. Conceptions of deontology and ethics, patient rights and their applications in the World and Turkey are taught to students.

(ECZ381) PHARMACOGNOSY I (T)      

HOUR /WEEK :2, ECTS :3

This course deals with the general features, classification, identification, estimation, isolation, biological activity and indication of some crude drugs including carbohydrates (monosaccharides, oligosaccharides, polysaccharides), cardiac glycosides, saponins, cyanogenic glycosides, glucosinolates, anthraquinones have been described.

(ECZ382) PHARMACOGNOSY II (T)           

HOUR/WEEK :2, ECTS :2

This course deals with the general features, classification, identification, estimation, isolation, activity and indication of some crude drugs including flavonoids, anthocyanins, phenolic glycosides, coumarins, tannins, lipids, terpenoids and volatile oils have been described.

(ECZ383) PHARMACOGNOSY I PRACTICE (P)             

HOUR / WEEK :4, ECTS:2

In this laboratory, microscopically analysis, pharmacopeial analysis, isolation methods qualitative and quantitative estimation of some drugs including, carbohydrates (monosaccharides, oligosaccharides, polysaccharides), cardiac glycosides, saponins, cyanogenic glycosides, glucosinolates, anthraquinones have been done.

(ECZ384) PHARMACOGNOSY II PRACTICE (R)               

HOUR / WEEK :4, ECTS:4

In this laboratory, microscopically analysis, pharmacopeial analysis, isolation methods qualitative and quantitative estimation of some drugs including, flavonoids, anthocyanins, phenolic glycosides, coumarins, tannins, lipids, terpenoids and volatile oils have been done.

(ECZ385) PHARMACEUTICAL CHEMISTRY I (T)                

HOUR /WEEK  :4, ECTS:5

The mission of the Pharmaceutical Chemistry I course is to introduce students to the chemical formula, general physico-chemical and structural properties, synthesis, chemistry of metabolites structure-activity relationships of pharmaceutical agent. Topics include introduction to pharmaceutical and medicinal chemistry, a. Drug active material design and development methods, b. Quantitative Structure Activity Relationship (QSAR), chemistry of drug metabolism, Local and general anesthetics, Sedative and Hypnotic drugs, Tranquillizer drugs, Neuroleptic drugs, Myorelaxant and antiepileptic drugs, Antidepressant drugs, Narcotic analgesic drugs, Non-narcotic analgesic drugs ,Non-steroidal Anti-inflammatory Drugs.

(ECZ386) PHARMACETICAL CHEMISTRY II (T)                 

HOUR/WEEK :3, ECTS :4

Pharmaceutical Chemistry II provides the general aspects of drug molecules consisting of their chemical structures, chemical nomenclature, physicochemical properties, synthesis schedules, metabolism, stabilities, chemical analysis and their interaction with biological systems. Under this generalization, chemotherapy and chemotherapeutics, beta-lactam antibiotics, beta-lactamase inhibitors, antibiotics derived from polypeptides, macrolitics, aminoglycosites, other antibiotics (tetracyclines, chloramphenicol), sulfonamides, quinolone compounds, antituberculosis drugs, antifungals, antiviral drugs and antineoplastic drugs, are counted.

(ECZ387) PHARMACEUTICAL CHEMISTRY PRACTISE  I (P)                  

HOUR/WEEK :4, ECTS:2

The experimental studies of Pharmaceutical Chemistry I covers the generalized topics for laboratory safety, laboratory devices and the usage techniques along with separation of organic molecules and purification in which a) Crystallization, b) Extraction, c) Distillation, d) Chromatography (thin-layer, column, paper), e) Capillary electrophoresis, f) HPLC methods are considered.  Additionally, computer-aided drug design and development methods including 1) Quantitative structure-Activity Relationships (QSAR), 2) Molecular Modeling Techniques are performed with using computer programs such as Minitab, ChemSketch, and ChemDraw.

(ECZ388) PHARMACEUTICAL CHEMISTRY PRACTISE II (P)                   

HOUR /WEEK :4, ECTS:4

The synthesis of certain chemical compounds which are supposed to bear drug-like properties and/or drug starting chemicals are performed, such as 1) Iodophorm, 2) Benzyl alcohol, 3)  p_Nitrosoacetanilide, 4) Hydrolysis of Aspirin, 5) Benzocaine, 6) Benzoine, 7) Benzyl, and 8) Benzylic acid. The course curriculum also covers the synthesis of compounds such as, 1) Benzilidene aniline, 2) Phenyl azo beta-naphthol, 3) Hydrolysis of p-Nitroacetanilid, 4) Ethyl acetate, 5) Acetanilide, 6) Dibenzalacetone, 7) Benzyl phenoxime, 8) Diazoaminobenzene.

(ECZ389) PHARMACEUTICAL TECHNOLOGY- I (T)                   

HOUR/WEEK :3, ECTS:4

Introduction to pharmaceutical technology, Pharmaceutical measurements and units, Preparation and control of water for pharmaceutical usage (Distilled water, etc.) Preformulation, Properties of active agents (Stability, Solubility, Dissolution rate, etc.), Unit operations (Drying, Grinding, etc.), Pharmaceutical solutions, Extraction technology and pharmaceutical preparations prepared by extraction, Dressing materials and surgical materials, Classification of dressing materials (samples, properties and controls).

(ECZ390) PHARMACEUTICAL TECHNOLOGY- II (T)                   

HOUR WEEK :3, ECTS :4

 Colloids and multi-phased systems, Suspensions (Classification of disperse systems, formulation of suspensions, zeta potential, sedimentation of suspensions, rheology, preparation, particle size and distribution), Emulsions (Classification, emulsifying agents, HLB value, Preparation, emulsion formation theories, etc.), Semisolid preparations (skin structure and properties, factors affecting dermal absorption, bases, penetration enhancers, types and acting mechanisms. Semi solid bases, Preparation methods of semisolids, required controls in semisolids). Suppositories and ovules (Suppository bases, Production technology of and drug release). Cosmetics and applications (Cosmetic products, Regulations in Turkey and world, Cosmeceuticals, Principles of formulation design in cosmetics, quality controls, final product specifications and quality controls).

(ECZ391) PHARMACEUTICAL TECHNOLOGY PRACTICE- I (P)                   

HOUR / WEEK :4, ECTS:3

Prescription balance, drop weight (drop count and dropping techniques),  electrical top balance, controls on distilled and deionized water, effects of solid particle sizes, movement of solvent and physicochemical state on dissolution, Alcoholic camphor solution, alibour solution, aluminum subacetate solution and determination of Baume degree in liquids, lime water, Ethanol-Iodine solution (TF 1974), Lugol’s solution, Iodine glycerin solution, Glycerin-Phenol solution, determination of free iodine quantity, Diluted hydrogen peroxide solution, simple syrup, mint water, resorcin-salicylic acid solution, determination of active chloride quantity, neutral sodium hypochlorite solution, magnesium citrate lemonade,  Glass container controls, rubber cap controls, hydrophilic cotton controls, hydrophilic gauze controls, Practical applications

(ECZ392) PHARMACEUTICAL TECHNOLOGY PRACTICE- II (P)                   

HOUR / WEEK :4, ECTS:3

Lotion, Kaolin-Pectin suspension, Determination of precipitation rate in suspensions, Surface activeness, Olive oil emulsion, Viscosity measurement methods, Liquid paraffin emulsion I, Liquid paraffin emulsion II, Simple ointment, Hydrophilic ointment, Glycerin ointment, O/W type cream, Wilkinson ointment, zinc oxide gelatin, depilatory cream, Zinc oxide ointment, Zinc oxide paste, investigations on properties of different ointment bases and investigation of drug release from ointments, Ichthyol ovule, glycerin suppository, Lipstick, vanishing cream, cleansing cream, paracetamol suppositories, chloralhydrate suppositories, investigation of in-vitro drug release from suppositories, practical applications.

(ECZ393) PHARMACOLOGY I (T)                   

HOUR /WEEK :4, ECTS:5

General Principles: Pharmacokinetics; The dynamics of drug absorption, distribution and elimination Pharmacodynamics; Mechanisms of drug action, Relationship between drug concentration and effect, Receptors, Relationship between drug and receptor Drug-Drug Interactions; Pharmacodynamic drug-drug interactions, Pharmacokinetic drug-drug interactions Toxic Effects Of Drugs; “Mechanism-based” adverse drug reactions, “Idiosyncratic” adverse drug reactions, Teratogenicity, Hypersensitivity reactions Drugs Affecting Autonomic Nervous System; Neurotransmission: The autonomic nervous system and somatic motor nervous system, Muscarinic receptor agonist and antagonists, Anticholinesterase agents, Agents acting at the neuromuscular junction and autonomic ganglia, Catecholamines, Sympathomimetic drugs and adrenergic receptor antagonists Drugs Acting On The Central Nervous System; Medications for the treatment of Parkinson Disease, Medications for the treatment of epilepsies (Antiseizure drugs), Medications for the treatment of anxiety, hypnotics and sedatives, Stimulants of central nervous system, Anesthetics, Antidepressants, Antipsychotic agents, Opioid analgesic and antagonists, Drugs of abuse Drugs Affecting Cardiovascular System; Medications for the treatment of the congestive heart failure, Antiarrhythmic drugs, Medications for the treatment of the angina pectoris, Antihypertensive agents, Drug therapy for hypercholesterolemia and dyslipidemia, Anticoagulant and thrombolytic agents, Hematopoietic agents, Drugs effective in iron deficiency and other hypochromic anemias.

(ECZ394) PHARMACOLOGY II (T)                   

HOUR / WEEK  :3, ECTS:3

Drugs Affecting Endocrine System; Pituitary and hypothalamus hormones, Thyroid and antithyroid drugs, Insulin, Oral hypoglycemic drugs, Adrenocortical steroids, Adrenocortical antagonists and adrenocorticotropic hormone, Androgens, Anabolic steroids and antiandrogens, Estrogens, Progestins and antiprogestins, Hormonal contraceptives Chemotherapy Of Microbial And Neoplastic Diseases; General considerations of therapy of microbial diseases, Antifolate drugs, Beta-lactam and other cell-wall and membrane active antibiotics, Protein synthesis inhibitors, Quinolones and agents for urinary tract infections, Antimyobacterial drugs, Antifungal agents, Antiprotozoal drugs, Antiparasitic agents, Antiviral agents, Antineoplastic agents Autacoids; Products of cyclooxygenase, Products of lipoxygenase, Histamine and antihistaminic drugs, Serotonin receptor agonists and antagonists, Medications for the treatment of migraine, Renin-angiotensin system, Angiotensin receptor antagonists and angiotensin converting enzyme inhibitors, Bradykinin and kallidin and their antagonists, Endotelins and nitric oxide Drugs Affecting Gastrointestinal Function; Agents used for treatment of peptic ulcers, Laxatives, Drugs stimulating gastrointestinal motility and antiemetic agents, Antidiarrheal agents, Pancreatic enzyme supplements, Bile acid therapy for gallstones.

(ECZ395) CLINICAL BIOCHEMISTRY (T)                   

HOUR /WEEK :1, ECTS :2

Units in Clinical Biochemistry, Material collection, Parameters effecting test results, Drug interferences, Disorders of Carbohydrate Metabolism; Diabetes Mellitus, Disorders of Endocrine Functions; Thyroid function tests, Liver function tests and assessment, Lipids and dislipidemias, Renal function tests and assessment, Water and electrolytes, Acid base balance, Ca and Phosphor, Tests for Cardiovascular diseases, Blood analysis, Case discussions.

(ECZ396)  PHYSIOPATHOLOGY (T)

HOUR/WEEK :2, ECTS:2

Pathophysiology of diseases: Hypertension, heart failure-shock, arrhythmia, atherosclerotic heart disease, peptic ulcer, inflammated bowel diseases, liver diseases, constipation and diarrhea, gout, inflammation and Immunity, acute and chronic renal failure, Iymphoma, leukemia, rheumatoid arthritis, osteoporosis, thyroid gland diseases, diabetes mellitus, chronic obstructive pulmonary disease, tuberculosis. Definition and mechanisms of inflammation, hypoxia, ischemia, cyanosis. Regulation of body temperature and pathophysiology of fever. Definition, mechanism and types of pain. Vascular fluid regulation, pathophysiology of edema, clinical types of edema. Fluid-electrolyte balance and disturbances, hypervolemia and hypovolemia. Acid-base balance and disturbances. Kidney function disturbances. Kidney failure. Atherosclerosis, coronary artery diseases, myocard infarction pathophysiology. Definition of hypertension, Causes of primary and secondary hypertension, mechanisms and complications. Mechanisms of heart failure, left and right heart failure, pulmonary hypertension. Definition of shock, pathophysology, causes and types of shock. Causes of obstructive and restrictive respiratory diseases. Pathophysiology of allergy, anaflaxia and asthma. Mechanisms of hypothalamus-hypophysis axis disorders. Pathophysiology of hyperthyroidism and hypothyroidism. Bone and mineral metabolism and disorders. Disorders of blood glucose regulation: hyperglycemia and hypoglycemia. Pathophysiology and complications of peptic ulcer. Causes and mechanisms of diarrhea and constipation. Disorders of gall bladder and bile duct, causes of jaundice. Liver function disorders. Liver failure and hepatitis. Definition, mechanisms, reasons and types of anemia. White blood cell disorders, leucopenia, leukocytosis, leukomoid reaction, lymphoma and leukemias. Disorders of homeostatic regulation  I: Vascular and coagulation disorders. Disorders of homeostatic regulation  II: Thrombocyte disorders and disseminated intravascular coagulation. Autoimmune and collagen tissue disorders.

(ECZ481) PHARMACOGNOSY III (T)                    

HOUR/WEK :2, ECTS :3

Definition of alkaloids distribution in plant kingdom will be described. Classification, botanical source, pharmacological activity and uses of alkaloids will be given. Further information will be mentioned about isolation, identification and analysis of these active alkaloidal substances. Information on enzymes, protits, vaccines and serums also will be given.  

(ECZ483) PHARMACOGNOSY III PRACTICE (P)                      

HOUR/WEEK :4, ECTS:3

Microscopic characters, identification, isolation, pharmacopeial analysis, qualitative and quantitative analysis of the drugs containing alkaloid substances will be given experimentally.  

(ECZ485) PHARMACEUTICAL CHEMISTRY III (T)                        

HOUR/WEEK :2, ECTS:2

The mission of the Pharmaceutical Chemistry III course is to introduce students to the chemical formula, general physico-chemical and structural properties, synthesis, chemistry of metabolites structure-activity relationships of pharmaceutical agent. Topics include Cholinergic drugs: 1. Parasympathomimetics, 2. Anti-cholinesterase drugs, Neuromuscular blocking drugs, ganglion blocking drugs, sympatholytics, cardiovascular system drugs: anti-anginal drugs, anti-arrhythmics, anti-hyperlypidemics, anti-coagulants, trombolytics and anti-platelets.

(ECZ482) PHARMACEUTICAL CHEMISTRY IV (T)                       

HOUR/WEEK :2, ECTS:3

The mission of the Pharmaceutical Chemistry IV course is to introduce students to the chemical formula, general physico-chemical and structural properties, synthesis, chemistry of metabolites structure-activity relationships of pharmaceutical agent. Topics include gastrointestinal system drugs, intestinal drugs, emetics and anti-emetics, diagnostic drugs, respiratory system drugs, oral antidiabetics, antihypoglycaemics, hormones, steroid hormones, ovarian- sex hormones, androgen- sex hormones, thyroid hormones and anti-thryroid compounds

(ECZ487) PHARMACEUTICAL CHEMISTRY III PRACTICAL (P)                        

HOUR/WEEK :4, ECTS:3

The aim of Pharmaceutical Chemistry III Practical course is to give a general knowledge about analysis of functional groups of organic substance and biologically important compounds using instrumental analysis methods. Topics include 1. Analysis of functional groups of organic substance, 2. Instrumental analysis methods, a. Ultraviolet and visible spectroscopy, b. Infrared spectroscopy and interpretation techniques, c. Nuclear magnetic resonance spectroscopy and interpretation techniques, d. Mass Spectroscopy and interpretation techniques, 3. Instrumental analysis methods and spectrum interpretation techniques

(ECZ484) PHARMACEUTICAL CHEMISTRY IV PRACTICAL (P)                       

HOUR/WEEK :4, ECTS:2

The aim of Pharmaceutical Chemistry IV Practical course is to give a general knowledge about organic synthesis reactions. Topics include the synthesis of 1. Iodoform, 2. Acetanilide, 3. p-Nitro acetanilide, 4. Ethyl p-aminobenzoate, 5. 2,4-Dihydroxyacetophenone, 6. Phenothiazine, 7. Benzoic acid, 8. Benzoin, 9. Benzyl, 10. Benzylic acid.

(ECZ489) PHARMACEUTICAL TECHNOLOGY III (T)                       

HOUR/WEEK :3, ECTS:3

Powder technology, solid dosage forms and their technology (mixing of powders, mixed powders and packages, granules and effervescent granules, pilules and sachets. Hard and soft gelatin capsules and micropellets, microspheres. Tablet technology, tablet pressing physics, encapsulation

(ECZ486) PHARMACEUTICAL TECHNOLOGY IV (T)                       

HOUR /WEEK :4, ECTS:4

Parenteral solutions (osmoses, diffusion and dialyze, isotonic and isohidri, parenteral production technology, filtration and ultra filtration, sterilization), eye, nose and ear drops, stability of drugs and reaction kinetics, incompatibility, biopharmaceutics and pharmacokinetics, radiopharmaceuticals.

(ECZ491) PHARMACEUTICAL TECHNOLOGY PRACTICE III (P)                        

HOUR/WEEK :4, ECTS:2

Carbomedicinalis package, eutectic mixtures, granules and effervescent granules, investigations of particle size distribution and flow properties of granules, capsule production, physical controls in capsules, tablets and their controls, gelatin lozonage, aerosol production and controls,  prescription practices  subjects are investigated.

(ECZ488) PHARMACEUTICAL TECHNOLOGY PRACTICE IV (P)                        

HOUR/WEEK :4, ECTS:4

Parenteral solutions, drops (eye, nose and ear drops), sterile neutral olive oil, stability test for aspirin, incompatible prescriptions, in vitro dissolution test for solid dosage forms, industrial production for syrups, emulsions and ointments and prescription practices are investigated.

(ECZ493) PHARMACEUTICAL TOXICOLOGY THEORY I (T)                        

HOUR /WEEK :2, ECTS:3

General information about toxicology and poisons; Entrance ways and absorption of poisons; Metabolism of toxic substances; Toxicokinetics; Mechanisms of toxic effects; Genetic toxicology; Chemical mutagenesis; Chemical carcinogenesis Teratogenesis; Systemic toxicology; Investigation of toxicity and risk analyses; First aid in acute poisonings and principles of antidote treatment.

(ECZ490) PHARMACEUTICAL TOXICOLOGY THEORY II (T)                         

HOUR/WEEK :2, ECTS:3

Drug toxicity; Drug interactions; Drug abuse and dependence; Pesticides; Airborne poisons; Organic solvents; Metallic poisons; Radiation and radioisotopes; Natural poisons; Poisons of plant and animal origin.

(ECZ495) PHARMACEUTICAL TOXICOLOGY PRACTICE I (P)                         

HOUR/WEEK :2, ECTS:2

Aim and general information; Phase I (EROD and cotinine) tests; Isolation and current use of genomic DNA molecule from biological samples; Genotyping 1 (gene deletion, GSTM 1, GSTT1), Genotyping 2 (SNP, GSTP1); Genotyping 3 (cut product); Genotoxicity tests used to identify chromosomal damage [Sister Chromatid Exchange (SCE) and micronucleus test (MN)]; Indication of potential antioxidant substances (DPPH, glutathione); Lipid peroxidation; Cytotoxicity; Investigation of acute toxicity; Evaluation of teratogenic effects of chemical substances using inseminated chicken embryo. 

(ECZ492) PHARMACEUTICAL TOXICOLOGY PRACTICE II (P)                         

HOUR/WEEK :4, ECTS:2

General information; Isolation and indication of ethyl alcohol from blood; Investigation of cyanide and carbon monoxide in blood; Liquid-liquid chromatographic isolation and defining tests of  barbiturates; Identification of lead by dithisone extraction method; Indication of ALA from urine to evaluate the lead exposure; Toxicological analyses in food samples; Toxicological analyses performed in water, milk, dairy-products, and edible oil samples; Chromatographic separation and quantification methods used in toxicological analyses: Gas chromatography, thin layer chromatography; Narcotics and identification using thin layer chromatography.

(ECZ500) MEDICAL FIRST AID (T)                         

 HOUR/WEEK :1, ECTS:1

General principles of first aid , triage and transporting, cardio-pulmonary resuscitation,  airway obstruction, artificial respiration methods, shock, coma, bleeding, soft tissue injury, dressing and bandages, fractures, dislocations, sprains, burns, heat injuries, cold injuries  bites and stings, foreign bodies injuries, acute abdomen

(ECZ497) PHARMACEUTICAL LEGISLATION AND MANAGEMENT (T)                          

HOUR/WEEK :2, ECTS:3

Laws, by-laws and regulations about pharmacy in Turkey and applications of fundamental subjects of management in pharmaceutical administrations are taught to students in this lesson. Especially 6197, 6643, 984, 2313, 992, 767 numbered laws and their regulations are explained in this lesson and planning, production, finance, controlling and personnel management in pharmaceutical administration are particular subjects in this lesson.

(ECZ498)  FAMILY PLANNING (T) 

HOUR/WEEK :1, ECTS:1

The Definition of reproductive healthy Family Planning, General Principles, Aim of the Family Planning and Benefit of Family Planning, Population and Associated Factors The Population Politics in the World, Fertility and Associated Factors, Legal Status of Family Planning, the Anatomy and Physiology of Reproductive System, Counseling in Family Planning, Hormonal Contraceptives, Barrier Contraceptives, Intra Uterine Device, Sterilization, Traditional Contraceptives Methods, Other Contraceptives

(ECZ494) PHARMACOTHERAPEUTICS (T)                         

HOUR /WEEK :2, ECTS:3

General principles: Drug Development,. Pharmacogenetics,. Drug—drug Interactions, Adverse Drug Reactions, Drug Allergies and Drug-Induced Diseases, New Methods in Pharmacological Therapy,. Pharmacoeconomics, Pediatric and Geriatric Pharmacology; Drug Treatment of the Cardiovascular System: Ischemic Heart Disease: Angina pectoris and Myocardial infarction, Congestive Heart Failure, Hypertension, Hyperlipidemia; Drug Treatment of the Respiratory System: Bronchial asthma, Acute and Chronic Bronchitis; Drug Treatment of the Endocrine System: Diabetes mellitus, Thyroid Disorders; drug treatment of the gastrointestinal system: peptic ulcer.

(ECZ499) PHARMACOLOGY III (T)                          

HOUR/WEEK :2, ECTS:3

Drug Therapy Of Inflammation; Nonsteroidal anti-inflammatory drugs Drugs Affecting Respiratory System; Drugs used in asthma, Medications for the treatment of chronic obstructive pulmonary disease, Drugs used in rhinitis, Drugs used in the treatment of cough Drugs Affecting Renal Function; Diuretics Oxytocic Agents; Oxytocin, Ergot alkaloids Vitamins; Fat-soluble vitamins, Water-soluble vitamins.

(ECZ496) PHARMACEUTICAL CARE (T)

HOUR/WEEK :2, ECTS:3

Importance of pharmaceutical care for community health, improvement of communication with patients; Patients care methods; Patient compliance Development of patients education and health, Clinical pharmacokinetics, adjustment dosage forms of medication and therapeutic drug monitoring, Drug interactions and importance of adverse reactions; Profiles of hospital and community pharmacy patients (database); Drug information systems, Introduction to Clinical Pharmacy and Pharmaceutical Care, Basic applications in clinical pharmacy, Drug usage in risk group patients and the role of pharmacist. The role of pharmacists in gastrointestinal tract disorders, liver diseases, kidney diseases, endocrine system diseases, pulmonary diseases, cardiovascular diseases, rheumatoid diseases and infectious disorders. Patient Oriented Pharmacy, Definiton, History and Education Programs. Roles of Clinical Pharmacist. Systematic Approach to Drug Therapy - Case Study. Drug Information Tools. Patient Drug Profile and computer use in patient oriented practice. Clinical Pharmacists' Approach to Pain and Fever Cases . Pharmaceutical care in Diarrhea and Constipation. Patient Counseling and Compliance in Clinical Pharmacy Practice. Patient Education Techniques and Effective Communication in Pharmacy Practice. Proper Use of Pharmaceutical Dosage Forms. Role of the Clinical Pharmacist in Asthma and COPD Management and use of inhalers. Drug Use in Pregnancy and Lactation - Clinical Pharmacists' Approach to acute and chronic problems. Pharmaceutical Care in Peptic Ulcer and Helicobacter pylori treatment. The Role of Clinical Pharmacist in Hypertension Treatment. Recent Advance in Hyperlipidemia Treatment and Clinical Pharmacists' Role. Pharmaceutical Care in Diabetes.

 

* Ist Group Elective Courses (ECZ-601-606)

ECZ601 BEHAVIOURAL SCIENCES (T)

HOUR/WEEK :2, ECTS:2

Behavioral sciences encompasse all the disciplines that explore the activities of and interactions among individuals in the natural world. This lecture describes different disciplines that observe behavior. It involves the evolution of behavior, behavioral learning approach, cognitive learning approach and factors affecting learning. Students are provided with a basic knowledge in language and communication, motivation, emotions and emotional behavior as well. Pharmacy students also get advanced knowledge in drugs that alter behavior with a different perspective such as stimulants, sedative-hypnotics, hallucinogen drugs, etc.

ECZ602 DEVELOPMENTAL PSYCHOLOGY (T)

HOUR/WEEK :2, ECTS:2

This lecture starts with a description of development, and its, maturation and learning, and life long development. It also provides a general knowledge about puberty, prepuberty and physical developmental at the beginning and end of puberty. Erikson’s Psychosocial Development Theory, and the theories of Piaget and Kohlberg and several factors that affect individual’s development (such as family, friends and physical development) will be covered.

ECZ603 PRINCIPLES OF LAW  (T)

HOUR /WEEK :2, ECTS:2

This course deals with the regulations of a society and the interaction of law with the social structure and individual rights. A general introduction to the scientific examination of law in terms of branching and specialization is provided. Constitutional law and the conflicts between law and constitution are within the scoop of this course. The students also learn the sources powered by law and how to reach the written resources of law

ECZ604  INTRODUCTION TO SOCIOLOGY (T)

HOUR/WEEK :2, ECTS:2

Following titles are dealt with in this lecture: What is science? What is sociology? What are their branches? Individual and society: interaction, daily life, socialization, personality, statue, group. Society: classification, culture, cultural differences, roles, institutions, ethnicity and race. Movements in a society. Social regulations: unity, crime. Democracy, multiculturalism, modernity and postmodernity.

ECZ605 PUBLIC RELATIONS (T)

HOUR /WEEK :2, ECTS:2

The beginning and development of public relations and communication, the factors of basic communication such as aim, message, communication channel, feedback, and communication period are covered in this lecture. Also, the differences between advertisement and public relations are discussed. Other titles in this lecture include: description of administrative structure to public, understanding of public expectations and needs, tools in public relations, public relations in crisis management.

ECZ606 GENERAL ACCOUNTING (T)

HOUR/WEEK :2, ECTS:2

This course aims to provide a general knowledge in accounting. It starts with an introduction to and description of accounting: history, mandatory books, optional books, legal rules to bookkeeping. Other major titles include: Financial statement and its qualifications, classification of balances, theories in financial statement; Balance in accounting: how to open or close an account; End of the year statement; Inventory and record keeping.

 

**IInd Group Elective Courses (ECZ 701-733)

(ECZ701)  INSTRUMENTAL ANALYSIS (T)

HOUR/WEEK :2, ECTS:2

The aim of this course is to give the students a theoretical and practical knowledge in the use of instruments for analysis. The content of this course; technical information, glassware, chemicals, Optical methods: spectrophotometry, spectrofluorimetry, atomic absorption spectrometry, atomic emission spectrometry, refractometry, polarimetry, Chromatographic methods: thin layer chromatography (TLC), high performance liquid chromatography (HPLC), gas chromatography (GC), Electroanalytical methods: potentiometry, voltammetry, polarography, conductometry, amperometry Other spectroscopic methods: nuclear magnetic resonance spectroscopy (NMR), electron spin resonance Spectroscopy (ESR), mass spectroscopy (MS), Thermal analysis: thermal gravimetry (TG), differantial thermal analysis (DTA), differantial scanning calorimetry (DSC) and, capillary electrophoresis (CE), ion selective electrodes and flow injection analysis (FIA).

(ECZ702) COMPUTER USAGE AND CALCULATION IN ANALYTICAL CHEMISTRY (T)

HOUR/WEEK :1, ECTS:1

The aim of this course is to teach the calculations used in analytical chemistry by supporting the computer. The content of this course; Analytical model designs depending on parameters such as temperature, pressure, pH, wavelength, absorbance, fluorescence and chromatographic separation capacity in analytical methods, regression analysis, algorithm preparation and its utilization for calibration, calculation of selectivity and sensitivity in calibration, transformation methods for signals used in analysis. The usage of computer programmes and calculations in application of analytical methods, basic mathematical calculations, purity (or impurity) calculations in analysis, analytical laboratory equipments and their calibrations.

(ECZ703) PLANT NARCOTICS AND PSYCHOTROPS (T)

HOUR/WEEK: 1, ECTS: 1

Definition of narcotic and psychotropic substances of plant origin will be described. Classification, source, use and active plant-originated substances with narcotics and psychotropic properties will be given. Further information will be mentioned about identification and analysis of these active substances. In the society, addiction problems of narcotic and psychotropic substances will also be discussed.

(ECZ704) HERBAL DRUG RAW MATERIALS (T)

HOUR/WEEK: 1, ECTS: 1

Introduction, Features of medicinal plants, Use of medicinal plants, Obtaining of raw material from medicinal plants, Drug raw materials, source plants and effects ( ephedrine, colchicines, taxol, vincristine, quinine, digitoxine, atropine, scopolamine, pilocarpine, reserpine, ergotamine, essin, gingko glycosides, ruscogenine, sennozit A and B, passiflora extract, hesperidins, physostigmine, galantamine, huperzine, alpha lipoic acid, pectin, lycopene, glucosamine, resveratrol, etoposide etc.). Introduction, the aim of the primary screening, the aim of the secondary screening, antibacterial activity tests in plant extracts, antifungal activity tests in plant extracts, anti-inflammatory activity tests in plant extracts, analgesic activity tests in plant extracts, hepatoprotective  activity tests in plant extracts, spasmolitic activity tests in plant extracts, antitumoral activity tests in plant extracts acute toxicity test in plant extracts.

(ECZ705) HERBAL TEAS (T)

HOUR/WEEK: 1, ECTS: 1

The concept and definition about herbal teas, preparation techniques, classification based on indication (respiratory system disorders, digestive system disorders etc.) of mixed herbal teas have been described. Also biological activities, toxic effects and interactions of the plants in each group will also be discussed.

(ECZ706) NATURAL PRODUCTS FROM MARINE SOURCES (T)

HOUR/WEEK: 1, ECTS: 1

Classification of marine organisms, chemical structure and biological activities of the compounds from these organisms, mechanisms of activity and potential applications are explained.

(ECZ 707) BIOLOGICAL EFFECTS OF THE NATURAL PRODUCTS (T)

HOUR/WEEK: 2, ECTS: 2

Introduction, the aim of the primary screening, the aim of the secondary screening antibacterial activity tests in plant extracts, antifungal activity tests in plant extracts, anti-inflammatory activity tests in plant extracts, analgesic activity tests in plant extracts hepatoprotective  activity tests in plant extracts, spazmolitic activity tests in plant extracts antitumoral activity tests in plant extracts, acute toxicity test in plant extracts.

(ECZ708) AROMATHERAPY (T)

HOUR/WEEK: 1, ECTS: 1

The concept and the definitions about the subject, aromatherapy application ways and fields, the essential and carrier oils used in aromatherapy and aromatherapy formulations have been described.

(ECZ709) VITAMIN AND MINERALS AND RICHED NATURAL PRODUCTS (T)

HOUR/WEEK: 1, ECTS: 1

General concepts, activity, toxic effects, classification, of vitamins and minerals, multivitamin preparations and vitamin and mineral riched natural products will be discussed.

(ECZ710)  POISONOUS PLANTS of TURKEY (T)

HOUR/WEEK :1, ECTS:1

What is poison?, What is intoxication?, The Importance of Poisonous Plants in Turkish Flora, Toxic Compounds in Poisonous Plants, Classification of Plants According to Their Toxic Content, Relation Between Poisonous and Medicinal Plants, Poisonous Plants of Turkey, Plant Poisoning in Turkey, Important Notes in Poisoning

(ECZ711)  PHYTOCOSMETICS (T)

HOUR/WEEK :1, ECTS:1

Today, the usage of plants in cosmetics increases conspicuously. Global tendency to the natural products also strengthens this deal. Plants with cosmetic importance and the uses of these plants are the main scopes of this course. Information about EU criteria for phytocosmetics is also included.

(ECZ712)  MORPHOLOGICAL and ANATOMICAL CHARACTERISTICS of HERBAL DRUGS (T)

HOUR/WEEK :1, ECTS:1

Identification of morphological and anatomical characteristics of medicinal plants is very important for the determination of purity and quality of  herbal drugs. Morphological and anatomical characteristics of herbal drugs listed in “European Pharmacopoeia” and “ESCOP (The European Scientific Cooperative on Phytotherapy) Monographs” and also the medicinal plants used in Turkish Folk Medicine are within the scope of this course. The essentials of  herbal drug preparation and preservation are also mentioned. The main titles are: Leaf, Cortex, Underground Plant Parts, Aerial Plant Parts (Herba), Flower, Fruit, Seed, Others. 

(ECZ713)  ANTISEPTIC, DESINFECTANT AND THE DRYGS USED FOR THE VARIABLE INFECTIONS (T)

HOUR/WEEK :2, ECTS:2

The mission of the Antiseptics, Disinfectants and the drugs used for the variable infections course is to introduce students to the chemical formula, general physico-chemical and structural properties, Synthesis and chemistry of pharmaceutical agents. Topics include I.Antiseptic and Disinfectant drugs II-Anthelmintic drugs III-Antiprotozoer drugs 1-Antimalarial drugs 2-Antiamibic drugs 3-Drugs used for Leishmaniasis 4-Antitrichomonal drugs 5-Drugs used for Trypanosome IV-Drugs used for ectoparasites.

(ECZ714)  DRUG DESİGN AND THE METHODS (T)

HOUR/WEEK :1, ECTS:1

The Importance of Rational Drug Design Methods, Effector-Target Relationships, Physicochemical Parameters, Quantitative Structure-Activity Relationship Analysis, Hansch Analysis, Free-Wilson Analysis, Mixed Analysis, 3-Dimensional Quantitative-Structure Activity Relationship Analysis, CoMFA and CoMSIA Analysis, Molecular Modeling Techniques, DeNovo Analysis

(ECZ715) GENOMICS AND CHEMOINFORMATICS IN MEDICINAL CHEMISTRY (T)

HOUR/WEEK :1, ECTS:1

This course introduces an overview of chemistry and classification of bioactive materials, macromolecular targets in medicinal chemistry, genomic studies in drug design, genomics, proteomics, chemoinformatic, pharmacogenomics, and applications of genomics in drug design, bioorganic chemistry, and synthesis of peptides, oligonucteotides, nucleosides, nucleic acids and enzymatic reagents.

(ECZ716)  ISOMERS AND DRUG ACTIVITY (T)

HOUR /WEEK :1, ECTS:1

Stereoisomerism and physicochemical and structural properties of stereoisomers. Stereoisomerism of  drug active material and the behavior of stereoisomers in biological conditions and their activity differences. The discussion of pharmacological, toxicological, pharmacokinetic and pharmacoeconomic results of different biological answers based on these differences.

(ECZ717)  CHEMICAL ANALYSIS AND EVALUATION ON BIOAVAILABILITY (T)

HOUR/WEEK :1, ECTS:1

This course introduces an overview of general description of bioavailability, importance of bioavailability in treatment, examples and comparison of bioavailability of drugs, basics of bioavailability and bioequivalence, oral bioavailability of drugs, physicochemical parameters, analysis of body fluids, evaluation of bioanalytical methods and validation.

(ECZ718)  COSMETICS AND THEIR APPLICATION AREAS (T)

HOUR/WEEK :2, ECTS:2

Introduction, definitions, legal arrangements in Turkey for cosmetic products, FDA, COLIPA and Japanese regulations. Classification of cosmetic products, skin and the structure and characteristics of skin parts, importance from the cosmetic point of view. Cosmeceuticals, their classification, their usage purpose. General raw materials used in cosmetic formulations. Cosmetic products applied to the skin, formulation designs and their production. Cosmetic products applied to the skin parts, formulation designs and their production (cosmetic products which applied to hair, nails and mucous membranes). Controls on the prepared cosmetic products, determination of the final product specifications. Stability tests which are applied to the cosmetic products (physical, chemical and microbiological stability investigations). Side effects of cosmetic products.

 

(ECZ720)  DESIGN AND DEVELOPMENT OF DRUG FORMULATIONS IN INDUSTRIAL PHARMACY (T)

HOUR/WEEK :2, ECTS:2

Investigations of physico-pharmaceutical specifications of drugs. Investigations of form characteristics of drugs. Investigations of treatment specifications of drugs. Investigations of interactions between drugs and drug substances. Investigations of interactions and constitutional specifications of products. Formulation design and basic data in formulation development. Arrangement and investigation of technological parameters belonging to the new drug forms.  Investigation on the basic criterion for the optimization of production parameters. Technological optimization and stepped study design. Industrial production designing and study procedure for big scale production. Investigation of the factors which effects production, investigation of machine parking dependence. Arrangement of process and in-process controls. Evaluation and application of national and international production parameters.

(ECZ724) PROCEDURE ENGINEERING IN PHARMACEUTICAL TECHNOLOGY (T)

HOUR/WEEK :1, ECTS:1

Basic subjects ( gas and liquid flow, heat transfer, mass transfer, powders), unit operation (air filtration, humidity and heat, drying poeration, solid-liquid extraction, evaporation and distillation, filtration, grinding operation, mixing operation, sterilization).

(ECZ727)  PROCESS VALIDATIONS IN PHARMACEUTICAL TECHNOLOGY (T)

HOUR /WEEK :1, ECTS:1

Legal principals of process validation. Validation organization. Prospective process validation. Retrospective process validation. Revalidation. Process qualification. Validation of sterile products. Validation of solid dosage forms production. Validation of semisolid dosage forms production. Validation of unit dose sprays. Process validation and quality assurance (QA). Cleaning validation. Raw material (Input) validation.

(ECZ728)  FORMULATION DESIGN AND QUALITY CONTROL PROCESS OF HERBAL MEDICINAL DRUGS (T)

HOUR/WEEK :1, ECTS:1

Preparation methods of herbal medicinal drugs (as liquid dosage forms, capsules, tablets, transdermal formulations, particular dosage forms, compress and bolus), Biopharmaceutical characterization of herbal medicinal drugs, Standardization of herbal medicinal drugs, Bioavailability of herbal medicinal drugs, Stability of herbal medicinal drugs, Quality assurance of herbal medicinal drugs, Dosage forms of herbal medicinal drugs and GMP.

(ECZ729)  BASIC PHARMACEUTICAL PROCESSES (T)

HOUR/WEEK :1, ECTS:1

Selection of parameters to investigate, depending on the dosage form to be developed.  Selection of parameters to investigate, depending on active agent.  Selection of parameters to investigate, depending on polymer and excipients. Solubility and dissolution rate mechanism and determination in media and polymer. Determination of diffusion coefficient and its importance in bioavailability. Determination of partition coefficient and its importance in formulation. Particle size analysis and its importance in formulation.

(ECZ730) DRUG SAFETY AND RISK ASSESSMENT IN DRUG USE (T)

HOUR/WEEK: 2, ECTS:2

Introduction of drug safety;  Role of risk assessment in risk management; Constituting risk information during clinical trials; Special issues that must be taken into consideration during risk assessment; Pre-clinic and clinic studies before approval stage of drug; Adverse drug reactions (ADRs) and pharmacovigilance; Importance of pharmacovigilance and ADR monitoring centers; Importance of adverse drug reactions (ADR) in terms of patient harm and deaths; Post-marketing monitoring and reports of ADR; Withdrawal of drugs from market due to toxic effects; Classification of adverse drug effects and type A adverse reactions; Type B adverse reactions: Idiosyncratic reactions and underlying factors; ADRs not dependent to dose; Hypersensitivity; Allergy; Allergic drug reactions, anaphylaxis and serious dermal reactions; Photoallergy; Hepatotoxicity and blood discrasies; Induction and inhibition; Safety of vegetal drugs; Adverse effects due to genetic polymorphism in drug metabolizing enzymes; Polymorphism of Cytochrome P450 (CYP) and Phase II   enzymes; Drug safety in future

(ECZ731) GENETIC FACTORS IN EFFICIENT DRUG USE (T)

HOUR/WEEK:1, ECTS:1

Role of interindividual genetic differences in drug use; Mechanisms of interindividual genetic differences in drug use; The toxicity originated from interindividual genetic differences in drug use; Genetic polymorphisms related with Phase I enzymes; The role of Phase I enzyme polymorphisms in drug toxicity; Genetic polymorphisms related with Phase II enzymes; The role of Phase II enzyme polymorphisms in drug toxicity and resistance; Bioinformatics; Cytogenetic tests in analysis and assessment of toxicity of drugs and toxic chemical substances; The importance of toxicogenetics in exposure to chemical carcinogens and mutagens; Drug-gene interactions and immune system diseases; The genetic factors in use of antineoplastic drugs.

(ECZ732 ) PROFESSIONAL ENGLISH I (T)

HOUR/WEET: 2, ECTS:2

The course topic is to develop professional English by studying on English manuscripts, literatures and phrases through question-answer exercises, translations and oral presentations.

(ECZ733 ) PROFESSIONAL ENGLISH II (T)

HOUR/WEEK: 2, ECTS:2

The course topic is to develop professional English by studying on English manuscripts, literatures and phrases through question-answer exercises, translations and oral presentations.

 

(ECZ506) GLP GOOD LABORATORY PRACTICES (T)

HOUR/WEEK : 2, ECTS: 2

Job and responsibility distribution Ratios of reference and test materials to be analyzed Devices and materials, Reagents, Physical and chemical test systems, Biological test systems Determination of test and reference materials, Sampling and keeping test and reference materials Standard working methods, Planning of a study, Result report and content, Destruction of analytical wastes, Keeping conditions of analytical samples, Pharmaceutical analysis according to pharmacopoeia, ISO 9001 quality management system.

 

(ECZ 507) ANALYTICAL VALIDATION (T)

HOUR/WEEK : 2, ECTS: 2

Definition, Calculation of linear equation and related parameters, Validation parameters, Accuracy and precision, Repeatability, Limit of detection, Limit of quantification, Linearity, Working range, Ruggedness, Robustness, Errors (simple, systematic, nonsystematic, standard), Confidence limit, Non-linear equations and their calibrations, Standard addition and calculations, System suitability tests (HPLC, spectrophotometry and electroanalytical techniques).

 

(ECZ508) DRUG AND ACTIVE COMPONENT ANALYSIS IN BIOLOGICAL SYSTEMS (T)

HOUR/WEEK : 2, ECTS: 2

Biological samples and acquiring, Sample preparing techniques, In-vitro drug analysis in biological fluids, Optimization of drug analysis in biological fluids, Drug analysis in real biological fluids, Optimization of drug analysis in real biological fluids, Acceptability parameters of drug analysis in biological samples, Introduction to electrochemistry, Electrochemical DNA biosensors, Investigation DNA-drug interaction with biosensors, Drug analysis in biological fluids with biosensors, Analysis with ion-selective electrodes, Analysis in biological fluids with modified electrodes, Interpretation of results.

 

(ECZ546) ANALYSIS TECHNIQUES OF ACTIVE COMPONENT AND DRUG (T)

(In Association with Pharmaceutical Chemistry Department)

HOUR/WEEK : 2, ECTS: 2

Pretreatment in active component analysis, method selection in active component analysis (qualitative and quantitative), determination criteria of optimum conditions in analysis, calibration types that is used in active component analysis, non-aqueous titrations in  active component analysis, analysis techniques and method development depends on complex formation in active component analysis, spectrophotometric, spectrofluorometric analysis  and method development  in active component analysis, use of chromatographic techniques in active component analysis and method development, capillary electrophoretic analysis  and method development  in active component analysis, electroanalytical techniques  and method development in active component analysis, other techniques and method development in active component analysis (polarimetry, refractometry, thermal analysis etc.), application of these techniques to various formulations.

(ECZ 547) ANALYSIS TECHNIQUES OF ACTIVE COMPOUND AND DRUG (T)

(In Association with Pharmaceutical Chemistry Department)

HOUR/WEEK : 2, ECTS: 1

Pka determination of novalgine by spectrophotometric methods, pka determination of aspirin by spectrophotometric methods, determination of binary mixtures of paracetamol and caffeine in pharmaceutical dosage forms by spectrophotometric methods, determination of binary mixtures of paracetamol and caffeine in pharmaceutical dosage forms by spectrophotometric methods, determination of aspirin in pharmaceutical dosage forms by HPLC, determination of aspirin in biological samples by HPLC, quantitative determination of paracetamol by capillary electrophoresis, functional group analysis of sulphonamide by NMR (1H, 13C) spectroscopy, analysis of antipyrine by mass spectroscopy (ESI), quantitative analysis of aspirin by acid-base titration, functional group analysis of phenobarbital by FTIR spectroscopy, quantitative analysis of phenothiazine by FTIR spectroscopy, functional group analysis of sulphadimidine by UV spectroscopy, quantitative analysis of sodium barbital by UV spectroscopy.

(ECZ 549) NUTRITIONAL BIOCHEMISTRY (T)

HOUR/WEEK : 2, ECTS: 2

Human nutrition and its importance, digestion and absorption of major nutrients, carbohydrates as nutrients lipids as nutrients, proteins as nutrients, vitamins and minerals as nutrients, energy needs of human body nutrition in physiologic and pathologic conditions, total parenteral and enteral nutrition.

(ECZ550) METABOLIC INTERACTIONS AND REGULATION (T)

HOUR/WEEK : 2, ECTS: 2

Carbohydrate metabolism and regulation, carbohydrate metabolism and regulation, lipid metabolism and regulation, lipid metabolism and regulation, protein metabolism and regulation, protein metabolism and regulation, energy supply during sarved and fed state, energy requirement and caloric homeostazis, mechanisms associated with the transformation between fed and starved states in liver, type ı and type ıı diabetes, fuel requirement at aerobic and anaerobic exercises, alterations and requirements in pregnancy and lactation, metabolic changes in stress and injury, glutamine metabolism.

(ECZ551) FREE RADICALS AND ANTIOXIDANTS (T)

HOUR/WEEK : 1, ECTS: 1

Introduction to free radicals, mechanism of free radical effect, endogenous source of free radicals, exogenous source of free radicals, free radical damage, oxidative stress and diseases, oxidative stress and diseases, oxidative stress and aging, antioxidative defence mechanism, antioxidant enzymes, enzymatic antioxidants, nonenzymatic antioxidants, antioxidants in nutrition, oxidative stress determination techniques

(ECZ509) GENERAL ETHICS – PHARMACY ETHICS AND PHARMACIST – PATİENT COMMUNICATION (T)

HOUR/WEEK : 2, ECTS: 2

General Conceptions and Definitions, Phylosophy and Ethics, Moral and Ethics, Deontology and Ethics, Bioethics, Ethical Principles, The Place of Ethical Principles in the Pharmaceutical Ethical Principles, Respect for the Autonomy of Others, Benevolence: Doing Good, Preventing Harm

Basic Justice: Being Fair, Ethical Principles in Pharmacy, Ethical Problems in Pharmacy Ethical Dilemma, Decision Making Process of Ethics, Communication Methods, Behaviour of Patients’ and Patients’ Relatives’, Organization of the Places where Pharmacists and Patients can meet in Independent Pharmacies and Hospital Pharmacies, Important Points in Pharmacist-Patient and Pharmacist-Patient’s Relatives Meetings, Medicinal Consultancy in Independent Pharmacies and Hospital Pharmacies, Feedback in Pharmacist-Patient Communication and Benefiting from this Feedback, Case Studies.

(ECZ510) RESEARCH METHODS IN HEALTH SCIENCES AND LITERATURE RESEARCH (T)

(In Association with Pharmaceutical Chemistry Department)

HOUR/WEEK : 1, ECTS: 1

Scientific Research and Its Qualities (Definition, Brief History, Purpose), Research Types Preparation Phase in Research, Choosing Subject, Data Collection Methods, Sampling Inquiry Method, Measurement Processes, Scales, Analyzing the Data, Literature and its Definition Libraries and Documentation Centres, Internet, Electronic Libraries, Databases and Using them Preparation and Writing of Research Project Proposal, Formation and Writing of Article and Thesis.

(ECZ 511) PRODUCTION AND MARKETING MANAGEMENT AND ORGANIZATION IN PHARMACY ADMINISTRATIONS

HOUR/WEEK : 2, ECTS: 2

General Conceptions, Definitions, Administrating and Management Functions and their, Applications on Pharmaceutical Administrations, Legislation about Pharmacies, Pharmaceutical Warehouses and Pharmaceutical Industry, Job Descriptions, Sections, Related Personnel in Pharmacies, Pharmaceutical Warehouses and Pharmaceutical Industry,  Production Management Strategies in Pharmaceutical Industry, Relationships of Production Department with Other Departments, Production Types and Management in Pharmaceutical Industry, Production Costs and Management in Pharmaceutical Industry, Marketing in Pharmaceutical Industry, Market and Marketing Research, Strategical Marketing Studies and Competition, Relationships of Marketing Department with Other Departments in Pharmaceutical Industry, Selection and Education of Marketing Personnel in Pharmaceutical Industry, Organization of Independent and Hospital Pharmacies, Production Management in Independent Pharmacies and Hospital Pharmacies Drug Distribution Systems, Managerial and Organizational Relationships of Hospital Pharmacies with Other Units.

(ECZ514) PHYTOMEDICINES I (T)

HOUR/WEEK:2, ECTS:2

Basic concepts and terms of phytotheraphy, phytomedicines used in the central nervous system disorders, phytomedicines used in the gastrointestinal and biliary system disorders, phytomedicines used as laxative, purgative and antidiareic, phytomedicines used in the endocrine system disorders, phytomedicines used in the immune system disorders, phytomedicines used as antioxidant, phytomedicines used for the diet.

(ECZ515) PHYTOMEDICINES II (T)

HOUR/WEEK:2, ECTS:2

Phytomedicines used for the skin disorders, phytomedicines used in the urinary system disorders, phytomedicines used as analgesic and antirheumatic, phytomedicines used in the respiratory system disorders, phytomedicines used in the reproductictive system disorders, phytomedicines used for the eye disorders, phytomedicines used in the cardiovascular system disorders, phytomedicines used as aphrodisiac.

(ECZ516) NATURAL PRODUCTS USED IN ONCOLOGY (T)

HOUR/WEEK:1, ECTS:1

The cancer diseases and the role of plants in cancer treatments, the effect mechanism of the compounds from natural sources in treatment, vincristine, vinblastine, vindesin, podophyllotoxin and derivatives, colchicine and maytansine, taxol and derivatives ındicine-n-oxide, camptothecin, ellipticines, cucurbitacines, phyllantoside, 4-ipomeanol and other tumor inhibitors.

(ECZ517) NUTRACEUTICALS  (T)

HOUR/WEEK:1, ECTS:1

Nutraceuticals: Term and History, The classification of nutraceuticals, The economical importance of  nutraceuticals, Nutraceuticals in isoprenoid structure, Nutraceuticals in phenolic structure, Nutraceuticals in protein/ aminoacid  structure, traceuticals in carbohydrate  structure, Nutraceuticals in lipid and fatty acid  structure,  minerals, Probiotics and prebiotics, The protective effects of nutreceuticals ogainst same diseases, authorization methods of natraceuticals.

(ECZ 518) CHROMATOGRAPHIC ANALYSİS AND STANDARDIZATION OF HERBAL PRODUCTS  (T)

HOUR/WEEK : 2, ECTS: 2

Meaning of standardization on herbal products, standardization methods and giving examples, methods used for standardization, quality and quality control on herbal products necessary analysis for legislation of herbal products, development and validation of method of  analysis for herbal products, standardization analysis of phytoterapeutics, analsis of sedative drugs, analysis of laxative, purgative and antidiareic drugs, analysis of cardiovascular system drugs, analysis of urinary system drugs.

(ECZ519) PLANT BIOTECHNOLOGY  (T)

HOUR/WEEK : 1, ECTS: 1

Concept and history, Plant cells and organs, General laboratory setting; equipment ,chemicals, Techniques used in biotechnologie, Preparation and sterilisation of seeds and tissues, Plant growth regulators and media preparation, Root cultures, Callus cultures, Shoot cultures, Suspension cultures, Biotransformation, Construction of bioreactors, Industrial Production of secondary products, Biotechnologic products having economic value.

(ECZ512) DRUG INTERACTIONS  (T)

HOUR/WEEK : 2, ECTS: 2

Pharrmacodynamic interactions, Pharmacokinetic interactions, Drug-drug interactions, The effects of drugs on clinical laboratory test results, The interactions of oral anticoagulants, The interactions of antidiabetic drugs, The interactions of antihypertensive drugs, The interactions of chemotherapeutic drugs, The interactions of antineoplastic drugs, The interactions of cardiac glycosides, The interactions of monoamine oxidase drug inhibitors,The interactions of tricyclic antidepressants, The interactions of salisilates, Drug-food interactions.

(ECZ513) OTC DRUGS   (T)

HOUR/WEEK : 2, ECTS: 2

Oral and dental hygene products, Drugs for caugh and cold, Antiallergic drugs, Contact lens products, ophthalmic and otic drugs, Antacids, OTC H2 receptor blockers, Laxatives and antidiarrheic drugs Nutritional products and vitamins, Analgesics and antipyretics, Contraseptives, Weight management products, Sleep aids, Drugs for allergic rhinitis, Drugs for the treatment of acne.

(ECZ520) ETHNOPHARMACY and ALTERNATIVE THERAPY METHODS (T)

HOUR/WEEK : 2, ECTS: 2

Introduction to ethnobotany and ethnopharmacy, history of plant-human relationships, traditional usage of plants, conservation of ethnobotanical richness, ethnobotanical study techniques, ethnopharmaceutical, studies in drug discovery, aromatherapy, phytotherapy, homeopathy, kampo medicine, ayurvedic medicine, hydrotherapy.

(ECZ521) BIOLOGICAL RICHNESS of TURKEY (T)

HOUR/WEEK : 1, ECTS: 1

Flora of Turkey, comparison of richness of flora of Turkey with the floras of other countries, economic plants of Turkey, economic plants of Turkey, economic plants of Turkey, export plants of turkey, export plants of turkey, export plants of Turkey, some chemical and biological activity ınvestigations on plants of Turkey, some chemical and biological activity ınvestigations on plants of Turkey, products from plants of Turkey, products from plants of Turkey, medicinal plant potential of Turkey and some recommendations related to ıts evaluation, medicinal plant potential of Turkey and some recommendations related to ıts evaluation.

(ECZ545) PHYTOCHEMICAL SCREENING METHODS (T)

HOUR/WEEK : 1, ECTS: 1

What are the phytochemical screening methods?, what is the ımportance of active substance screening, methods in herbal products?, reaction types used in screening, properties sought in screening methods preparation of plant extracts, preparation of plant extracts, reagents used in phytochemical screening, alkaloid screening in plant materials, alkaloid screening in plant materials, saponoside and flavonoid screening in plant materials,volatile oil, anthraquinone and coumarin screening in plant materials, tannin and cardioactive heteroside screening in plant materials, cyanogenic heteroside screening in plant materials.

 (ECZ526) DRUGS USED İN HOSPITAL (T)

HOUR/WEEK : 1, ECTS: 1

Description of General Anesthesia and Introduction in General, anesthetic Drugs, Gases or vapors (inhalational anaesthetics), injections (intravenous anaesthetics), special Combination Anesthesia and the other applications, the organo diagnostics: radiopharmaceutics, x-ray contrast , compounds and the other diagnostic sistems (MR, CT, scintigraphy, etc.), diagnostics of metabolism, synthesis of drugs with iodo and radionucleid drugs, diagnostics of function, the antibacterial drugs used in hospitals,the oncology drugs used in hospitals, ganglioplegic drugs, intravitreal drugs and the others.

(ecz527) COMPUTATIONAL APPLICATIONS IN MEDICINAL CHEMISTRY  (T)

HOUR/WEEK : 1, ECTS: 1

Introduction to computer in medicinal chemistry, receptor concept, chemical bonds in drug-receptor ınteractions, drug targets, conformational analysis, pharmacophore analysis, pharmacophore analysis, database searching, docking applications, denovo design, presentations of softwares used in molecular modelling, presentations of softwares used in molecular modelling.

(ECZ528) METABOLISM IN DRUG DESIGN TIMETABLE OF THE CLASSES (T)

HOUR/WEEK : 1, ECTS: 1

Introduction to drug metabolism (biotransformation), reactions and pathways of metabolism, reactions and pathways of metabolism, drug design and development methods, importance of metabolites in pharmacological activity, metabolite effect on drug deactivation, metabolite effect on drug toxicity, metabolites that are responsible modifying pharmacological activity, drug design using metabolites and molecular modifications, drug design using metabolites and molecular modifications, drug design using metabolites and molecular modifications, drug design using absorption and transport properties of  metabolites.

(ECZ530) BIOTECHNOLOGY IN MEDICINAL  (T)

HOUR/WEEK : 1, ECTS: 1

Synthesis and introduction to biologically important peptide, oligonucleic chemistry. importance of biotechnology in synthesis, chemical structure of carbohydrates in drug formation, chemical properties of nucleic acid and importance of analogues of nucleosides in medication, biotechnological evaluation of enzyme and proteins. assessment of enzyme and proteins as receptors, biotechnological investigation of enzymatic reagents that assist reactions rate, recent biotechnological developments, classifications, synthesis and application of enzyme inhibitors, developments in the area of immune-organic chemistry, investigation of bioorganically catalyzed reactions, introduction of bioorganic receptors and interactions with drugs, classification and structural investigation of bioorganic pro-drugs and biopolymers, role of biotechnology in the development of synthesis of vitamins and hormones, biotechnological methods in drug development.

(ECZ531) DIVERSE DRUG CATEGORIES IN THERAPY (T)

HOUR/WEEK : 1, ECTS: 1

Respiratory stimulants and convulsion stimulants, Physicomotor stimulants and adrenergic stimulants Physicomimetic compounds (indolealkylamines), phenylalkylamines, opium and cannaboides, nootropics, 2-pyrolidone and pyridine derivatives, acridine and dimethylaminoethanol derivatives classification of antiparkinson drugs and dopaminergic compounds, precursors of dopamine and ergo alkaloids, dopamine antagonists, muscarinic compounds with antiparkinson activity, tertiary alcohol derivatives and benzhydrile ethers, structure activity relationships of dopamine antagonists, antialzheimer compounds and their structure activity relationships.

(ECZ532) AGRİCULTURAL AND VETERİNARY DRUGS  (T)

HOUR/WEEK : 1, ECTS: 1

Introduction to agricultural and veterinary drugs and general definition, studies on risk factors of agricultural drugs and precaution that is needed to be taken, poisoning with agricultural combat drugs and their antidots, rules for licensing agricultural drugs and related regulations, classification of agricultural drugs (insecticides, acaricides, medicines for seasonal combat, fumigants, nematocides, rodenticides, molluscicides, fungicides, herbicides), classification of agricultural drugs (insecticides, acaricides, medicines for seasonal combat, fumigants, nematocides, rodenticides, molluscicides, fungicides, herbicides), classification of agricultural drugs (insecticides, acaricides, medicines for seasonal combat, fumigants, nematocides, rodenticides, molluscicides, fungicides, herbicides), classification of agricultural drugs (insecticides, acaricides, medicines for seasonal combat, fumigants, nematocides, rodenticides, molluscicides, fungicides, herbicides), classification of agricultural drugs (insecticides, acaricides, medicines for seasonal combat, fumigants, nematocides, rodenticides, molluscicides, fungicides, herbicides), definition and classification of veterinary medicines (analgesics, analeptics, antihistaminic, chemotherapeutics, antiseptic and disinfectants, antiectoparasite medicines, anthelmintic medicines, vitamins and mineral compounds, hormones), definition and classification of veterinary medicines (analgesics, analeptics, antihistaminic, chemotherapeutics, antiseptic and disinfectants, antiectoparasite medicines, anthelmintic medicines, vitamins and mineral compounds, hormones), definition and classification of veterinary medicines (analgesics, analeptics, antihistaminic, chemotherapeutics, antiseptic and disinfectants, antiectoparasite medicines, anthelmintic medicines, vitamins and mineral compounds, hormones), definition and classification of veterinary medicines (analgesics, analeptics, antihistaminic, chemotherapeutics, antiseptic and disinfectants, antiectoparasite medicines, anthelmintic medicines, vitamins and mineral compounds, hormones), definition and classification of veterinary medicines (analgesics, analeptics, antihistaminic, chemotherapeutics, antiseptic and disinfectants, antiectoparasite medicines, anthelmintic medicines, vitamins and Mineral Compounds, Hormones).

(ECZ538) SYNTHESES of DRUG RAW MATERIALS and INGREDIENTS (T)

HOUR/WEEK : 1, ECTS: 1

Introduction to industrial drug synthesis, physical basics of organic reaction mechanisms, designing of synthesis, chemical process, combinatorial techniques in drug synthesis, synthesis of antibiotics and antibacterials, synthesis of opiates, synthesis of steroids, synthesis of cardiovascular drugs synthesis of some natural originated drugs, synthesis of radiopharmaceutics, synthesis of, organometallic drugs, developments and encountered problems.

(ECZ546) ANALYSIS TECHNIQUES OF ACTIVE COMPONENT AND DRUG  (T)

(In Association with Pharmaceutical Chemistry Department)

HOUR/WEEK : 2, ECTS: 2

Pretreatment in active component analysis, method selection in active component analysis (qualitative and quantitative), determination criteria of optimum conditions in analysis, calibration types that is used in active component analysis, non-aqueous titrations in  active component analysis, analysis techniques and method development depends on complex formation in active component analysis, spectrophotometric, spectrofluorometric analysis  and method development  in active component analysis, use of chromatographic techniques in active component analysis and method development, capillary electrophoretic analysis  and method development  in active component analysis, electroanalytical techniques  and method development in active component analysis, other techniques and method development in active component analysis (polarimetry, refractometry, thermal analysis etc.), application of these techniques to various formulations.

(ECZ 547) ANALYSIS TECHNIQUES OF ACTIVE COMPOUND AND DRUG  (T)

(In Association with Pharmaceutical Chemistry Department)

HOUR/WEEK : 2, ECTS: 1

Pka determination of novalgine by spectrophotometric methods, pka determination of aspirin by spectrophotometric methods, determination of binary mixtures of paracetamol and caffeine in pharmaceutical dosage forms by spectrophotometric methods, determination of binary mixtures of paracetamol and caffeine in pharmaceutical dosage forms by spectrophotometric methods, determination of aspirin in pharmaceutical dosage forms by HPLC, determination of aspirin in biological samples by HPLC, quantitative determination of paracetamol by capillary electrophoresis, functional group analysis of sulphonamide by NMR (1H, 13C) spectroscopy, analysis of antipyrine by mass spectroscopy (ESI), quantitative analysis of aspirin by acid-base titration, functional group analysis of phenobarbital by FTIR spectroscopy, quantitative analysis of phenothiazine by FTIR spectroscopy, functional group analysis of sulphadimidine by UV spectroscopy, quantitative analysis of sodium barbital by UV spectroscopy.

(ECZ522)  INFECTIOUS DISEASES AND EPIDEMIOLOGY OF HOSPITAL INFECTIONS     (T)

HOUR/WEEK : 2, ECTS: 2

Definitions about epidemiology and infectious diseases, transmission ways of ınfectious diseases and epidemical types epidemiology and control of common bacterial, viral, parasitic and mycotic infections in our country(microorganisms that causes hospital infections and epidemiology of hospital infection, prevention, control of hospital infections and antibiotic usage, eradication, control of agents that  resistant to several antibiotics and causes hospital infections and hospital hygiene

(ECZ523) MICROBIOLOGICAL ANALYSIS OF  PHARMACEUTICAL PREPARATIONS  (T)

HOUR/WEEK : 2, ECTS: 2           

Contamination sources on pharmaceutical products, classification of pharmaceutical preparations acoording to the fıp suggestions and microbial standartization, methods of counting microorganisms, ıdentification, isolation, transmission ways and properties of microorganisms that shouldn’t be in pharmaceutical preparations, microbiological limit tests of preparations that do or don’t have to be sterilized.

 (ECZ524)  INDUSTRIAL MICROBIOLOGY   (T)

HOUR/WEEK : 2, ECTS: 2

Industrial microbiology, utilized microorganisms and their manufacture, ındustrial fermentation, the utilized microorganisms, gene engineering in ındustrial microbiology, bacterial metabolism and its enzymes, manufacture of some products by fermentation and techniques used in industrial  microbiology.

(ECZ525) DETERMINATION of DISSOLUTION RATE on THE EVALUATION of DRUG FORMULATION and QUALITY CONTROLS and ITS  IMPORTANCE (T)

HOUR/WEEK : 1, ECTS: 1

Dissolution rate, definion and mechanisms, officinal methods given in pharmacopoeial monographs non-officinal methods, ımportance of dissolution rate from the point of bioequivalance, ımportance of dissolution methods on the evaluation of formulations, dissolution methods from the point of finished product quality control, classical dosage forms, controlled release dosage forms, evaluation of  dissolution rate data, alternative methods in bioavailability/bioequivalance determinations.

(ECZ533) DESIGN and APPLICATION on BIOAVAILABILITY/ BIOEQUIVALANCE  (T)

HOUR/WEEK : 1 , ECTS: 1

Pharmacokinetics, design of bioavailability practice, statistical methods and average bioavailability, ıntra- and ınter-  subject variabilities, cross experimental designs between two formulations, bioequivalance, chemical equivalance, pharmaceutical-generic equivalance and therapeutical, equivalance, therapeutical alternative and pharmaceutical alternative. 

(ECZ534) DRUG PREPARATION on HOSPITAL SCALE  (T)

HOUR/WEEK : 1, ECTS: 1

Preparation of Internally given drugs, preparation of externally applied drugs, preparation of parenterally applied drugs, serums, plasma expanders and large volume parenteral preparations (LVP), surgical and medicinal materials used in hospital practice and their controls

(ECZ535) SYSTEMS for CONTROLLED DRUG DELIVERY and DELIVERY MECHANISMS  (T)

HOUR/WEEK : 2, ECTS: 2

Terminology,  ınvestigations of active agent properties choosen for the controlled release, ınvestigations on the physicochemical properties of active agent, ınvestigations on the biopharmaceutical-pharmacokinetic properties of active agent, determination of dosage forms for controlled release , matrix type preparations, capsules, osmotic pumps, floating dosage forms, bioadhesive systems, microparticulate systems, dose design, other application areas, transdermal systems, parenteral systems, ımplant systems, ocular systems rectal and vaginal systems, nasal and pulmonary systems, buccal systems, selection of the polymer type  ınvestigation of the release mechanisms, regulations on the controlled release systems, application areas on veterinary medicine, application areas on agricultural drugs.

(ECZ536) RADIOPHARMACEUTICALS  (T)

HOUR/WEEK : 1, ECTS: 1

Radiopharmacy and definition, radiopharmaceutic and definion , radionuclide and ıts applications on the medicine and pharmacy, radioactivity and radiation, radioactive decomposition, methods used for the measurement of radioactivity, formulation design in radiopharmaceutics, labeling in radiopharmaceutics sterilization of radiopharmaceutics, storage of radiopharmaceutics -quality assurance of radiopharmaceutics legal regulations in radiopharmacy.

(ECZ537) BASIC PROCESS on THE DESIGN of DRUG FORMULATIONS  (T)

HOUR/WEEK : 1, ECTS: 1

Basic designs in evaluation of drug formulations in ındustrial pharmacy, investigation of techological parameters aimed to compose pharmaceutical forms in, industrial pharmacy, development of drug manufacturing parameters in ındustrial pharmacy , investigation of the factors affecting the manufacturing in industrial pharmacy, evaluation of  ın-process and process controls of drug manufacturing in industrial  pharmacy, national and ınternational regulations about the parameters of drug manufacturing in   industrial pharmacy, basic contents of stability tests applied in drugs, stability ınvestigations in drug manufacturing, preformulation and formulation steps national and ınternational conditions and regulations applied in stability tests of drugs,  ınvestigation on the expiry date of drugs, stability ınvestigations of pharmaceutical dosage forms, stability applications on pharmacy practice, stability applications on hospital pharmacy and clinical pharmacy.

(ECZ539) BIOTECHNOLOGY ORIGINATED PHARMACEUTICAL PRODUCTS and FORMULATION DESIGNS  (T)

HOUR/WEEK : 2, ECTS: 2

Definitions and application areas of biotechnology and pharmaceutical biotechnology, biotechnologically origined pharmaceutical products, characteristics of biotechnologically origined pharmaceutical products, structure and structural characteristics, preformulation and formulation characteristics, technological manufacturing parameters, stability characteristics, dosage form designs of biotechnologically origined pharmaceutical products, delivery routes of biotechnologically origined pharmaceutical products oral, parenteral, rectal, vaginal, dermal, ocular and nasal delivery, quality controls on biotechnologically origined pharmaceutical products, finished product, specifications and ınternational regulations 

(EZ540) CERTIFICATION PROCEDURES on DRUGS, COSMETICS and INTERMEDIATE PRODUCTS (T)

HOUR/WEEK : 1, ECTS: 1

Law and regulations directed to public in turkey, criteria for the certification of approval of ınnovator and generic drugs in turkey,  fda and emea regulations in certification of approval definition of ıntermediate product, criteria of manufacturing and ımportation of these products manufacturing and ımportation procedures of  cosmetic products.

(ECZ541) FORMULATION DESIGN and QUALITY CONTROL PRACTICE on COSMETIC PRODUCTS

HOUR/WEEK : 2, ECTS: 2

Introduction, definitions, ınternational and turkey regulations, related to the subject , classification of cosmetic preparations,  cosmetic « pharmaceutic « cosmeceutic relation,  cosmeceuticals, classification and purpose of  use, selection criteria of appropriate cosmetic vehicle system formulation studies determination of finished product specifications on the prepared cosmetic products stability tests applied on the cosmetic preparations, ınvestigation of physical stability, ınvestigation of chemical stability, ınvestigation of microbiological stability, examination on the microbiological stability results according to the regulations, evaluation of skin efficacy of cosmetic products by non-ınvasive techniques, adverse effects of cosmetic products.

(ECZ542) GOOD MANUFACTURING PRACTICE on PHARMACEUTICAL PRODUCTS – GMP  (T)

HOUR/WEEK : 1, ECTS: 1

International regulations, manufactured dosage forms, organisation and personnel, manufacturing places and equipments, controls on the raw material and package systems, manufacturing and process controls packaging and labeling, laboratory controls and recording systems, pharmaceutical checking systems and regulations.

 (ECZ529) THE TOXICOLOGICAL IMPORTENCE OF DRUG USAGE DURING PREGNANCY, CHILDHOOD AND OLD AGE PERIODS  (T)      

HOUR/WEEK : 1, ECTS: 1

The safety usage of drugs and basic concepts, drug kinetics during pregnancy, the analyses of possible harmful risk factors of using drugs during pregnancy, clinical findings of drug toxicities and measures taken during pregnancy, drug kinetics in newborns and children, toxicities related with drug use in newborns and children, treatment of drug toxicities during newborn and childhood, drug kinetics and drug toxicities during lactation the issues that must be taken into consideration about drug usage during lactation, drug kinetic in elderly, adverse reactions of drug use in elderly, evaluation of possible risk factors of drug use in elderly, the issues that must be taken into consideration about drug usage in elderly.

(ECZ543) COSMETIC TOXICOLOGY (T)

HOUR/WEEK : 1, ECTS: 1

The structure of skin and toxicological significance of percutaneous absorption, biotransformation of skin and toxicological significance, the acute and chronic toxicities of cosmetics, allergic contact dermatitis and irritant contact dermatitis, phototoxic and photoallergic contact dermatitis, photochemical carcinogenesis, the risk assessment of chemical ingredients of cosmetics, the carcinogenic and mutagenic risks of xenobiotics of cosmetics, the contaminants and ingredients of cosmetics causing adverse effects, skin care and make-up products, shampoos, hair dyes and permanent wave products, antibacterial agents, antiperspirants and deodorants perfumes and sun screen products, the regulations of chemical ingredients of cosmetics.

(ECZ544) TOXIC SUBSTANCES IN FOOD       (T)

HOUR/WEEK : 1, ECTS: 1

General principals of food toxicology, the chemical pollution (contaminants) in food, mycotoxins (aflatoxins, patulin…), chemical pollutants (N-nitrozo compounds) formed by chemical reactions in food, carcinogens formed during cooking (PAHs, pyrolysis products, acrilamids…), food additives and aims of using, the regulations of food additives in world and Turkey, the safety values of food additives in human (NOAEL, ADI, MPI…), the international agencies working for safety of food additives (WHO, codex Alimentarius Commissions, JECFA, FAO, FDA…), european union directives and E-codes, hereditary disease groups related with food, the role of nutrient elements in detoxification mechanism, the genetically modified food, the relationship between food, environment and cancer.

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